Vaccine Database
Evidence-based profiles for 20 vaccines. Each page includes benefit-risk scoring, disease data, adverse events, credible scientific debates, and international policy comparisons.
Routine Childhood & Adult Vaccines
13 vaccinesHepatitis B
Hepatitis B is a viral liver infection. In infants and young children, 90% of infections become chronic, leadi…
DTaP
DTaP prevents three distinct diseases. Diphtheria causes a throat membrane that can suffocate children — case …
Hib
Before the vaccine, Haemophilus influenzae type b was the leading cause of bacterial meningitis in children un…
PCV (Prevnar)
Streptococcus pneumoniae is a major cause of meningitis, sepsis, and pneumonia in children under 2. Before PCV…
MMR
Measles has an R0 of 12–18, making it the most contagious vaccine-preventable disease. Pre-vaccine USA: 3–4 mi…
Rotavirus
Rotavirus is the leading cause of severe diarrheal disease in infants and young children worldwide. Before vac…
Varicella
Varicella-zoster virus causes chickenpox — a highly contagious illness with itchy blisters, fever, and malaise…
Hepatitis A
Hepatitis A virus (HAV) is a self-limiting liver infection. Unlike HepB, it does not cause chronic disease. Ho…
HPV
Human papillomavirus is the most common sexually transmitted infection — nearly all sexually active adults wil…
MenACWY
Neisseria meningitidis causes two life-threatening presentations: meningitis (infection of the brain's protect…
RSV Protection
RSV is the leading cause of infant hospitalization in the US — responsible for 58,000–80,000 hospitalizations …
Zoster (Shingrix)
The same varicella-zoster virus (VZV) that causes childhood chickenpox lies dormant in nerve ganglia for life.…
IPV (Polio)
Poliovirus causes irreversible paralysis by destroying motor neurons in the spinal cord. Before vaccination, p…
Annual Vaccines
2 vaccinesInfluenza
Seasonal influenza infects 9–45 million Americans annually and kills 12,000–52,000 per year depending on strai…
COVID-19
SARS-CoV-2 caused a global pandemic responsible for 7+ million confirmed deaths (likely 20+ million excess dea…
Shared Decision Vaccines
1 vaccinesTravel Vaccines
4 vaccinesTyphoid
Typhoid fever is a systemic bacterial illness caused by Salmonella Typhi, endemic in South Asia, Southeast Asi…
Yellow Fever
Yellow fever is a hemorrhagic viral illness transmitted by Aedes mosquitoes in sub-Saharan Africa and tropical…
Rabies
Rabies is caused by lyssavirus transmitted through the bite of an infected animal. Once clinical symptoms appe…
Dengue
Dengue is the most rapidly spreading mosquito-borne viral disease globally — infecting 390 million people annu…